Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years

Methotrexate Induced Pancytopenia

The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. The typical toxicities can be predicted by the timing of drug administration, where mucositis occurs as an earlier effect, while myelosuppression and the sequelae of pancytopenia occur later after MTX administration. Despite these well-known toxicities, low dose MTX therapy can become proble...

A review of 25 years experience in 461 cases of pediatric abdominal mass

Background: Regarding the significance of abdominal masses in children, we aimed to identify the pathology of masses according to the age and sex groups. Materials and Methods: We retrospectively reviewed pathological reports of 461 patients with abdominal mass that underwent resection or biopsy during the study period (25 years). Results: One hundred and eighty six cases (40%) were non-neo...

Methotrexate induced neutropenia associated with coprescription of penicillins: serious and under-reported?

dens syndrome misdiagnosed as polymyalgia rheumatica, giant cell arteritis, meningitis or spondylitis: an analysis of eight cases. A et al. The prevalence of chondrocalcinosis in the elderly and its association with knee osteoarthritis: the Framingham study. Methotrexate induced pancytopenia is rare and concern for it should not limit its use SIR, I read with interest the article by Lim et al. ...

[Infantile spinal atrophy: our experience in the last 25 years].

OBJECTIVES To determine the incidence of spinal muscular atrophy (SMA) in our study population and genetic distribution and epidemiological and clinical characteristics and to analyze the level of care and development. MATERIAL AND METHOD Retrospective descriptive study of patients treated in our hospital in the past 25 years (from 1987 to early 2013), with a clinical and neurophysiological d...

Body Contouring Surgery: Our 5 Years Experience